Depends on where I'm going, what I'm doing, and what I'm wearing. Could be anything from a 1911, a .40 S&W, a .380, a 9mm, to a .22 mag. My favorite carry piece is a KelTec PMR 30 .22 mag . . . just under 20 ounces fully-loaded, reliable, & accurate; it also fits almost all of my 1911 holsters. I religiously practice carrying, drawing, & shooting all of my carry pieces; I shoot a lot, but ensure that I remain proficient with the handguns I may have to rely on (again) some day. I hope not, but one never knows.
Good choice, I really like my PMR 30.